Table 4.19 Results of studies of leukemia and residential exposure to EMF


Study
Main results: OR and 95% CI
(unless otherwise specified)
Additional notes

Studies of electric appliance

(Preston-Martin et al., 1988)
Electric blanket use:
Ever vs. never used:
AML 0.9 (0.5-1.6)
CML 0.8 (0.4-1.6)
Many potential risk factors analyzed
Information on electric blanket use included after the fact in questionnaire of on-going case-control studies
Information on response rate in controls not given
(Lovely et al., 1994)
Ever vs. never use
Any appliance 0.71 (0.41-1.2)
Razors 1.3 (0.80-2.2)
Hair dryers 0.38 (0.22-0.66)
Massage units 3.0 (1.4-6.3)
Majority of cases deceased - most of data from proxy respondents Small numbers of subjects

Study using wiring configuration

(Severson et al., 1988)
Residence where lived longest
OLCC 0.60 (0.29-1.2)
OHCC 0.77 (0.35-1.7)
VHCC 0.79 (0.22-2.9)
Reference: end pole
Refusal rate for measurements much higher among controls (27%) than cases (4.9%)
One-time measurements made in a limited number of houses (56%) since many subjects had moved recently

Studies using calculated magnetic fields

(Severson et al., 1988)
Magnetic fields
(Reference: 0-0.05 µT)
Residence where lived longest
0.051-0.199 µT 0.69 (0.37-1.3)
>0.2 mT 0.75 (0.31-1.8)
Refusal rate for measurements much higher among controls (27%) than cases (4.9%)
One-time measurements made in a limited number of houses (56%) since many subjects had moved recently
(Feychting & Ahlbom, 1994)
Magnetic fields closest to diagnosis
(Reference <0.09 µT) - Matched analyses
All leukemia 0.1-0.19 µT 1.0 (0.5-1.8)
>0.20 µT 1.1 (0.6-1.8)
AML 0.1-0.19 µT 1.5 (0.4-5.3)
>0.20 µT 2.2 (0.7-6.8)
CML 0.1-0.19 µT 1.3 (0.3-5.1)
>0.20 µT 3.2 (0.9-11)
CLL 0.1-0.19 µT 0.9 (0.4-2.2)
>0.2 µT 0.6 (0.3-1.6)
Cumulative exposure over 15 years
(Reference < 0.99 µT -years) - Matched analyses
All leukemia 1.0-1.99 µT -year 1.1 (0.6-2.2)
>2.0 µT -year 1.4 (0.8-2.3)
AML 1.0-1.99 µT -year 1.7 (0.4-6.6)
>2.0 µT -year 3.5 (1.0-12)
CML 1.0-1.99 µT -year 2.1 (0.3-15)
>2.0 µT -year 1.6 (0.6-4.8)
CLL 1.0-199 µT -year 1.0 (0.4-2.6)
>2.0 µT -year 1.0 (0.4-2.2)
Same as above
(Feychting et al., 1997)
Magnetic fields closest to diagnosis
Subjects with only residential exposure (i.e. with occupational exposure < 0.13µT)
(Reference < 0.2 µT) - Unmatched analyses
All leukemia > 0.2 µT 0.9 (0.4-1.8)
AML > 0.2 µT 1.3 (0.4-5.0)
CML > 0.2 µT 0.5 (0.1-3.9)
CLL > 0.2 µT 0.8 (0.3-2.3)
Same as above
(Verkasalo, 1996)
Magnetic fields - highest annual average exposure
(Reference < 0.1 mT)
All leukemia (No. of exposed cases)
0.10 - 0.19 µT (ND) 1.1 (0.60-2.0)
0.20 - 0.29 µT (ND) 1.2 (0.40-3.3)
>0.30 µT (ND) 0.53 (0.16-1.7)
CLL
0.10 - 0.19 µT (5) 1.0 (0.37-2.5)
0.20 - 0.29 µT (1) 1.4 (0.16-11)
>0.30 µT (2) 0.87 (0.20-3.8)
Magnetic fields - cumulative exposure
(Reference < 0.40 µT-years)
CLL
0.40 - 0.99 µT-years (8) 0.98 (0.45-2.2)
1.00 - 1.99 µT -years (3) 1.3 (0.37-4.4)
>2.00 µT -years (3) 1.7 (0.48-5.8)
Cumulative exposure
CLL
> 0.20 µT -years vs. < 0.20 µT -years
< 5 years before
diagnosis (12)
0.93 (0.48-1.8)
5 - 9 years (11) 1.5 (0.72-3.1)
10 years (9) 2.8 (1.1-7.4)
> 0.40 µT -years vs. < 0.40
< 5 years (5) 0.84 (0.32-2.2)
5 - 9 years (5) 1.4 (0.52-4.0)
> 10 years (6) 4.6 (1.4-15)
Duration of exposure to magnetic fields
(Reference < 3 years)
3 - 5 years (1) 0.54 (0.90-3.0)
6 - 8 years (1) 0.55 (0.10-3.0)
9 - 11 years (1) 0.81 (0.15-4.5)
> 12 years (3) 4.8 (1.5-15)
Cohort study, SIRs
No information on other sources of residential EMF exposure
No direct information from study subjects
Cumulative exposure not treated as time dependent variable in the analyses
(Li et al., 1997)
Magnetic field exposure in year of diagnosis
(Reference < 0.1 µT)
0.1-0.2 µT 1.3 (0.8-1.9)
> 0.2 µT 1.4 (1.0-1.9)
Limited information on confounders because of restrictions on interview

Studies using direct residential measurements

(Severson et al., 1988)
Mean exposure from one time measurements
(Reference: 0-0.05 µT)
Low-power configuration
0.05-0.199 µT

1.2 (0.52-2.6)
> 0.2 µT 1.5 (0.48-4.7)
High-power configuration
0.05-0.199 µT

0.55 (0.25-1.2)
> 0.2 µT 1.6 (0.49-5.0)
Weighted mean exposure (vs. 0-0.5 mT)
Low-power configuration
0.05-0.199 µT

1.2 (0.54-2.5)
> 0.2 µT 1.0 (0.33-3.2)
High-power configuration
0.05-0.199 µT

0.91 (0.42-2.0)
> 0.2 µT 1.3 (0.35-4.5)
Refusal rate for measurements much higher among controls (27%) than cases (4.9%)
One-time measurements made in a limited number of houses (56%) since many subjects had moved recently
(Feychting & Ahlbom, 1994)
Spot measurements
(Reference <0.09 µT) - Matched analyses
All leukemia
0.10-0.19 µT 1.1 (0.7-1.9)
> 0.20 µT 1.2 (0.8-1.9)
AML
0.10-0.19 µT

0.9 (0.3-2.3)
> 0.20 µT 1.1 (0.4-2.4)
CML
0.10-0.19 µT

0.6 (0.1-1.8)
> 0.20 µT 1.5 (0.7-3.2)
CLL
0.10-0.19 µT

1.3 (0.7-2.6)
> 0.20 µT 0.9 (0.5-1.8)
Matched and unmatched analyses, adjusted or not for age and SES were carried out
No information on other sources of residential EMF exposure

AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; OLCC, ordinary low current configuration; OHCC, ordinary high current configuration; VHCC, very high current configuration; SES, socioeconomic status; CLL, chronic lymphocytic leukemia; ND, not determined; SIR, standardized incidence ratio